Nalmefene Hydrochloride Dihydrate

CHEMBL5315055 Phase 4 ได้รับการอนุมัติ Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

411.9 g/mol

LogP

—

Phase

4

A hydrochloride salt form of nalmefene with the same therapeutic properties. This medication is used to reduce alcohol consumption in adults who drink heavily, and it works by blocking opioid receptors in the brain that are involved in the rewarding effects of alcohol.

น้ำหนักโมเลกุล

411.9000 g/mol

TPSA

54.90 Å²

กลไกการออกฤทธิ์

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …

โครงสร้าง 2 มิติ

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SMILES

C=C1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5.Cl.O.O

InChI

InChI=1S/C21H25NO3.ClH.2H2O/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13;;;/h4-5,13,16,19,23-24H,1-3,6-11H2;1H;2*1H2/t16-,19+,20+,21-;;;/m1.../s1

Molecular Formula

C21H30ClNO5

HBD / HBA

5 / 6

พันธะที่หมุนได้

2

อะตอมหนัก

28

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

คำถามที่พบบ่อย

A hydrochloride salt form of nalmefene with the same therapeutic properties. This medication is used to reduce alcohol consumption in adults who drink heavily, and it works by blocking opioid receptors in the brain that are involved in the rewarding effects of alcohol.

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Yes, Nalmefene Hydrochloride Dihydrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5315055. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 46209574. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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โครงสร้าง

ข้อมูลด่วน

สูตร: C21H30ClNO5

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.