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Testolactone

CHEMBL1571 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
300.4 g/mol
LogP
3.0
Phase
4

Testolactone is a synthetic steroidal aromatase inhibitor that irreversibly inhibits the enzyme aromatase (CYP19A1), blocking the conversion of androgens to estrogens, and was historically used to treat advanced breast cancer in postmenopausal women. It has also been used in boys with familial male-limited precocious puberty (testotoxicosis) to reduce peripheral estrogen-driven epiphyseal maturation. It has largely been superseded by more potent and selective third-generation aromatase inhibitors such as anastrozole and letrozole.

น้ำหนักโมเลกุล

300.4000 g/mol

LogP

3.00

TPSA

43.40 Ų

Lipinski RO5

ผ่าน

Pharmacokinetics (PK)

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)OC(=O)CC[C@@H]12

                

                

                
                

                    
InChI

                    
InChI=1S/C19H24O3/c1-18-9-7-13(20)11-12(18)3-4-14-15(18)8-10-19(2)16(14)5-6-17(21)22-19/h7,9,11,14-16H,3-6,8,10H2,1-2H3/t14-,15+,16+,18+,19+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H24O3

                    

                    
                    

                        
HBD / HBA

                        
- / 3

                    

                    
                    

                        
พันธะที่หมุนได้

                        
0

                    

                    
                    
                    

                        
อะตอมหนัก

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Testolactone is a synthetic steroidal aromatase inhibitor that irreversibly inhibits the enzyme aromatase (CYP19A1), blocking the conversion of androgens to estrogens, and was historically used to treat advanced breast cancer in postmenopausal women. It has also been used in boys with familial male-limited precocious puberty (testotoxicosis) to reduce peripheral estrogen-driven epiphyseal maturation. It has largely been superseded by more potent and selective third-generation aromatase inhibitors such as anastrozole and letrozole.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Testolactone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1571.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 13769.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.