Testolactone

CHEMBL1571 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

300.4 g/mol

LogP

3.0

Phase

4

Testolactone is a synthetic steroidal aromatase inhibitor that irreversibly inhibits the enzyme aromatase (CYP19A1), blocking the conversion of androgens to estrogens, and was historically used to treat advanced breast cancer in postmenopausal women. It has also been used in boys with familial male-limited precocious puberty (testotoxicosis) to reduce peripheral estrogen-driven epiphyseal maturation. It has largely been superseded by more potent and selective third-generation aromatase inhibitors such as anastrozole and letrozole.

分子量

300.4000 g/mol

LogP

3.00

TPSA

43.40 Å²

Lipinski 五规则

符合

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)OC(=O)CC[C@@H]12

InChI

InChI=1S/C19H24O3/c1-18-9-7-13(20)11-12(18)3-4-14-15(18)8-10-19(2)16(14)5-6-17(21)22-19/h7,9,11,14-16H,3-6,8,10H2,1-2H3/t14-,15+,16+,18+,19+/m1/s1

Molecular Formula

C19H24O3

HBD / HBA

- / 3

可旋转键数

0

重原子数

22

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Testolactone is a synthetic steroidal aromatase inhibitor that irreversibly inhibits the enzyme aromatase (CYP19A1), blocking the conversion of androgens to estrogens, and was historically used to treat advanced breast cancer in postmenopausal women. It has also been used in boys with familial male-limited precocious puberty (testotoxicosis) to reduce peripheral estrogen-driven epiphyseal maturation. It has largely been superseded by more potent and selective third-generation aromatase inhibitors such as anastrozole and letrozole.

Yes, Testolactone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1571. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 13769. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C19H24O3

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.