Clearance (CL)
CLThe volume of plasma from which a drug is completely removed per unit time. Total clearance is the sum of renal clearance, hepatic clearance, and other routes. Determines steady-state concentration (Css = dose rate / CL).
ตัวอย่าง
- Renal CL of metformin
- Hepatic CL of propranolol
- CL = dose / AUC
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The volume of plasma from which a drug is completely removed per unit time. Total clearance is the sum of renal clearance, hepatic clearance, and other routes. Determines steady-state concentration …