Crossover Design
A clinical trial design in which each participant receives all study treatments in a sequence, with washout periods between treatments, serving as their own control. Crossover designs reduce inter-individual variability, require fewer participants than parallel designs, and are particularly efficient for pharmacokinetic bioequivalence studies. They are inappropriate for diseases that change over time or treatments with long-lasting effects.
ตัวอย่าง
- Bioequivalence studies: 2-period, 2-sequence crossover comparing generic vs. branded formulations
- Analgesic efficacy: 4-period crossover comparing acetaminophen, ibuprofen, combination, and placebo
- Antihypertensive comparison: AB/BA crossover with 2-week washout between drugs
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A clinical trial design in which each participant receives all study treatments in a sequence, with washout periods between treatments, serving as their own control. Crossover designs reduce inter-individual variability, …