Cytochrome P450 (CYP450)
CYP450A superfamily of heme-containing monooxygenase enzymes responsible for Phase I oxidative metabolism of ~75% of drugs. Key isoforms: CYP3A4 (50%), CYP2D6 (25%), CYP2C9, CYP2C19, CYP1A2.
ตัวอย่าง
- CYP3A4 inhibition by ketoconazole
- CYP2D6 poor metabolizers
- Grapefruit-CYP3A4 interaction
คุณรู้หรือไม่?
A superfamily of heme-containing monooxygenase enzymes responsible for Phase I oxidative metabolism of ~75% of drugs. Key isoforms: CYP3A4 (50%), CYP2D6 (25%), CYP2C9, CYP2C19, CYP1A2.