Drug-Induced Liver Injury (DILI)
DILIHepatotoxicity caused by medications, herbs, or supplements. The most common cause of acute liver failure in the US. Classified as hepatocellular, cholestatic, or mixed based on ALT/ALP ratio (R-value).
ตัวอย่าง
- Acetaminophen (dose-dependent)
- Isoniazid (idiosyncratic)
- Hy's Law: ALT >3x + bilirubin >2x
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Hepatotoxicity caused by medications, herbs, or supplements. The most common cause of acute liver failure in the US. Classified as hepatocellular, cholestatic, or mixed based on ALT/ALP ratio (R-value).