คำอธิบาย
Alprazolam and gabapentin produce additive CNS depression, increasing the risk of sedation, dizziness, and psychomotor impairment.
กลไก
GABA-A potentiation (alprazolam) combined with alpha-2-delta calcium channel modulation and GABAergic enhancement (gabapentin) produces additive CNS inhibition.
ความสำคัญทางคลินิก
Excessive sedation and ataxia are common with this combination; fall and fracture risk is substantially elevated.
การจัดการ
Use caution; reduce doses of both agents and advise against activities requiring alertness until tolerance to sedation is established.
ข้อจำกัดความรับผิดชอบทางการแพทย์
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.