คำอธิบาย
Ciprofloxacin and quetiapine both prolong the QT interval and ciprofloxacin also increases quetiapine exposure via CYP3A4 inhibition.
กลไก
Ciprofloxacin inhibits CYP3A4, reducing quetiapine clearance, while both drugs independently block hERG channels, creating dual pharmacokinetic and pharmacodynamic QT prolongation.
ความสำคัญทางคลินิก
Elevated quetiapine levels combined with additive QTc prolongation substantially raises the risk of life-threatening torsades de pointes.
การจัดการ
Avoid combination; select alternative antibiotics; if unavoidable, monitor ECG and consider temporary quetiapine dose reduction.
ข้อจำกัดความรับผิดชอบทางการแพทย์
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.