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Alosetron

CHEMBL1110 Phase 4 Onaylandı Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
294.4 g/mol
LogP
1.6
Phase
4

A selective serotonin 5-HT3 receptor antagonist that reduces the hypersensitivity and abnormal gut contractions characteristic of severe diarrhea-predominant irritable bowel syndrome (IBS-D) in women. By blocking these receptors in the gut, it slows intestinal transit, reduces urgency, and decreases pain.

Moleküler Ağırlık

294,3500 g/mol

LogP

1,60

TPSA

53,90 Ų

Lipinski RO5

Geçer

Etki Mekanizması

Increases water content in the intestinal lumen through osmotic or stimulant mechanisms, promoting bowel motility and facilitating defecation.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanizma

Increases water content in the intestinal lumen through osmotic or stimulant mechanisms, promoting bowel motility and facilitating defecation.

2D Yapı

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C17H18N4O/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2/h3-6,10H,7-9H2,1-2H3,(H,18,19)

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H18N4O

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Döndürülebilir Bağlar

                        
2

                    

                    
                    
                    

                        
Ağır Atomlar

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Sıkça Sorulan Sorular

                

                    
                    

                        
                        

                            
A selective serotonin 5-HT3 receptor antagonist that reduces the hypersensitivity and abnormal gut contractions characteristic of severe diarrhea-predominant irritable bowel syndrome (IBS-D) in women. By blocking these receptors in the gut, it slows intestinal transit, reduces urgency, and decreases pain.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Increases water content in the intestinal lumen through osmotic or stimulant mechanisms, promoting bowel motility and facilitating defecation.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Alosetron is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1110.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2099.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tıbbi Sorumluluk Reddi

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.