Amdinocillin Pivoxil
The orally active pivaloyloxymethyl ester prodrug of amdinocillin that is absorbed from the gut and converted to the active antibiotic form in the body. This prodrug formulation allows the otherwise poorly orally absorbed amdinocillin to be taken by mouth for treating urinary tract infections caused by gram-negative bacteria.
Moleküler Ağırlık
439,6000 g/mol
LogP
3,10
TPSA
114,00 Ų
Lipinski RO5
Geçer
Terapötik Alanlar
Etki Mekanizması
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
2D Yapı
Cite this structure
Embed this structure
SMILES
CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C
InChI
InChI=1S/C21H33N3O5S/c1-20(2,3)19(27)29-13-28-18(26)15-21(4,5)30-17-14(16(25)24(15)17)22-12-23-10-8-6-7-9-11-23/h12,14-15,17H,6-11,13H2,1-5H3/b22-12+/t14-,15+,17-/m1/s1
Molecular Formula
C21H33N3O5S
HBD / HBA
- / 7
Döndürülebilir Bağlar
8
Ağır Atomlar
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
The orally active pivaloyloxymethyl ester prodrug of amdinocillin that is absorbed from the gut and converted to the active antibiotic form in the body. This prodrug formulation allows the otherwise poorly orally absorbed amdinocillin to be taken by mouth for treating urinary tract infections caused by gram-negative bacteria.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Amdinocillin Pivoxil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1650818. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 115163. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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