Amiloride Hydrochloride

CHEMBL1398126 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

302.1 g/mol

LogP

—

Phase

4

The hydrochloride salt form of amiloride, an epithelial sodium channel blocker that promotes urine production while preserving potassium levels in the body. This formulation is used in combination diuretic regimens for hypertension and edema management.

Moleküler Ağırlık

302,1200 g/mol

TPSA

161,00 Å²

Terapötik Alanlar

Cardiovascular Disease Migraine Bipolar Disorder Gastroesophageal Reflux Disease Multiple Sclerosis Chronic Kidney Disease Obesity Type 2 Diabetes Hypertension Breast Cancer Heart Failure

Etki Mekanizması

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanizma

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

2D Yapı

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SMILES

Cl.N=C(N)NC(=O)c1nc(Cl)c(N)nc1N.O.O

InChI

InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2

Molecular Formula

C6H13Cl2N7O3

HBD / HBA

7 / 7

Döndürülebilir Bağlar

1

Ağır Atomlar

18

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

The hydrochloride salt form of amiloride, an epithelial sodium channel blocker that promotes urine production while preserving potassium levels in the body. This formulation is used in combination diuretic regimens for hypertension and edema management.

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Yes, Amiloride Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1398126. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 68540. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Hızlı Veriler

Formül: C6H13Cl2N7O3

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Tıbbi Sorumluluk Reddi

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.

Amiloride Hydrochloride

Terapötik Alanlar

Etki Mekanizması

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

Cite this structure

Embed this structure

No targets recorded

No interactions recorded

No side effects recorded

Sıkça Sorulan Sorular

References & Data Sources

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