Brexanolone

CHEMBL207538 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

318.5 g/mol

LogP

4.9

Phase

4

A synthetic form of allopregnanolone, a naturally occurring metabolite of progesterone, used for the treatment of postpartum depression in adults. It acts as a positive allosteric modulator of GABA-A receptors in the brain, restoring the balance disrupted after childbirth. It is administered as a 60-hour continuous intravenous infusion in a healthcare setting.

Moleküler Ağırlık

318,5000 g/mol

LogP

4,90

TPSA

37,30 Å²

Lipinski RO5

Geçer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

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SMILES

CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1

Molecular Formula

C21H34O2

HBD / HBA

1 / 2

Döndürülebilir Bağlar

1

Ağır Atomlar

23

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

A synthetic form of allopregnanolone, a naturally occurring metabolite of progesterone, used for the treatment of postpartum depression in adults. It acts as a positive allosteric modulator of GABA-A receptors in the brain, restoring the balance disrupted after childbirth. It is administered as a 60-hour continuous intravenous infusion in a healthcare setting.

Yes, Brexanolone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL207538. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 92786. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Formül: C21H34O2

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.