Cinoxacin
An older quinolone antibiotic used for the treatment and prevention of urinary tract infections caused by gram-negative bacteria, with a spectrum similar to nalidixic acid. It has been largely replaced by fluoroquinolone antibiotics with broader activity. It is no longer widely commercially available.
Moleküler Ağırlık
262,2200 g/mol
LogP
2,10
TPSA
88,40 Ų
Lipinski RO5
Geçer
Etki Mekanizması
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
2D Yapı
Cite this structure
Embed this structure
SMILES
CCn1nc(C(=O)O)c(=O)c2cc3c(cc21)OCO3
InChI
InChI=1S/C12H10N2O5/c1-2-14-7-4-9-8(18-5-19-9)3-6(7)11(15)10(13-14)12(16)17/h3-4H,2,5H2,1H3,(H,16,17)
Molecular Formula
C12H10N2O5
HBD / HBA
1 / 7
Döndürülebilir Bağlar
2
Ağır Atomlar
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
An older quinolone antibiotic used for the treatment and prevention of urinary tract infections caused by gram-negative bacteria, with a spectrum similar to nalidixic acid. It has been largely replaced by fluoroquinolone antibiotics with broader activity. It is no longer widely commercially available.
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Yes, Cinoxacin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1208. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2762. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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