Givinostat

CHEMBL1213492 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

421.5 g/mol

LogP

3.6

Phase

4

A histone deacetylase inhibitor that modifies gene expression in abnormal cells, used to treat polycythemia vera and investigated for other blood disorders and Duchenne muscular dystrophy. It works by blocking enzymes that suppress tumor suppressor genes, reducing the proliferation of abnormal blood cells. Clinical trials have also explored its ability to reduce muscle fibrosis in muscular dystrophy.

Moleküler Ağırlık

421,5000 g/mol

LogP

3,60

TPSA

90,90 Å²

Lipinski RO5

Geçer

Terapötik Alanlar

Lymphoma Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

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SMILES

CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(C(=O)NO)cc3)ccc2c1

InChI

InChI=1S/C24H27N3O4/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28)

Molecular Formula

C24H27N3O4

HBD / HBA

3 / 5

Döndürülebilir Bağlar

9

Ağır Atomlar

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

A histone deacetylase inhibitor that modifies gene expression in abnormal cells, used to treat polycythemia vera and investigated for other blood disorders and Duchenne muscular dystrophy. It works by blocking enzymes that suppress tumor suppressor genes, reducing the proliferation of abnormal blood cells. Clinical trials have also explored its ability to reduce muscle fibrosis in muscular dystrophy.

Yes, Givinostat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1213492. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 9804992. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Hızlı Veriler

Formül: C24H27N3O4
Eş Anlamlılar: 1

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.