Givinostat

CHEMBL1213492 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

421.5 g/mol

LogP

3.6

Phase

4

A histone deacetylase inhibitor that modifies gene expression in abnormal cells, used to treat polycythemia vera and investigated for other blood disorders and Duchenne muscular dystrophy. It works by blocking enzymes that suppress tumor suppressor genes, reducing the proliferation of abnormal blood cells. Clinical trials have also explored its ability to reduce muscle fibrosis in muscular dystrophy.

分子量

421.5000 g/mol

LogP

3.60

TPSA

90.90 Å²

Lipinski 五规则

符合

治疗领域

Lymphoma Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(C(=O)NO)cc3)ccc2c1

InChI

InChI=1S/C24H27N3O4/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28)

Molecular Formula

C24H27N3O4

HBD / HBA

3 / 5

可旋转键数

9

重原子数

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A histone deacetylase inhibitor that modifies gene expression in abnormal cells, used to treat polycythemia vera and investigated for other blood disorders and Duchenne muscular dystrophy. It works by blocking enzymes that suppress tumor suppressor genes, reducing the proliferation of abnormal blood cells. Clinical trials have also explored its ability to reduce muscle fibrosis in muscular dystrophy.

Yes, Givinostat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1213492. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 9804992. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C24H27N3O4
同义词: 1

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.