Idoxuridine
This antiviral drug works by incorporating into viral DNA in place of thymidine, disrupting replication of DNA viruses such as herpes simplex. It is used topically as eye drops to treat herpes simplex keratitis (viral eye infection) and as a skin cream for herpes labialis. It is too toxic for systemic use and is limited to topical applications.
Moleküler Ağırlık
354,1000 g/mol
LogP
-1,00
TPSA
99,10 Ų
Lipinski RO5
Geçer
Terapötik Alanlar
Etki Mekanizması
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
2D Yapı
Cite this structure
Embed this structure
SMILES
O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1I
InChI
InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
Molecular Formula
C9H11IN2O5
HBD / HBA
3 / 5
Döndürülebilir Bağlar
2
Ağır Atomlar
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
This antiviral drug works by incorporating into viral DNA in place of thymidine, disrupting replication of DNA viruses such as herpes simplex. It is used topically as eye drops to treat herpes simplex keratitis (viral eye infection) and as a skin cream for herpes labialis. It is too toxic for systemic use and is limited to topical applications.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Idoxuridine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL788. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5905. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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