Paclitaxel
A taxane chemotherapy drug that stabilizes microtubules in dividing cells, preventing them from completing cell division and causing cancer cell death. It is used to treat a wide range of cancers including breast, ovarian, lung, and Kaposi's sarcoma.
Moleküler Ağırlık
853,9000 g/mol
LogP
2,50
TPSA
221,00 Ų
Lipinski RO5
Başarısız
Terapötik Alanlar
Etki Mekanizması
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
2D Yapı
Cite this structure
Embed this structure
SMILES
CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O
InChI
InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
Molecular Formula
C47H51NO14
HBD / HBA
4 / 14
Döndürülebilir Bağlar
14
Ağır Atomlar
62
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
A taxane chemotherapy drug that stabilizes microtubules in dividing cells, preventing them from completing cell division and causing cancer cell death. It is used to treat a wide range of cancers including breast, ovarian, lung, and Kaposi's sarcoma.
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Yes, Paclitaxel is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL428647. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 36314. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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