Paclitaxel
A taxane chemotherapy drug that stabilizes microtubules in dividing cells, preventing them from completing cell division and causing cancer cell death. It is used to treat a wide range of cancers including breast, ovarian, lung, and Kaposi's sarcoma.
Peso Molecular
853,9000 g/mol
LogP
2,50
TPSA
221,00 Ų
Regra dos 5 de Lipinski
Reprovado
Áreas Terapêuticas
Mecanismo de Ação
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O
InChI
InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
Molecular Formula
C47H51NO14
HBD / HBA
4 / 14
Ligações Rotacionáveis
14
Átomos Pesados
62
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A taxane chemotherapy drug that stabilizes microtubules in dividing cells, preventing them from completing cell division and causing cancer cell death. It is used to treat a wide range of cancers including breast, ovarian, lung, and Kaposi's sarcoma.
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Yes, Paclitaxel is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL428647. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 36314. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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