Sulfathiazole
Sulfathiazole is a short-acting sulfonamide antibiotic used in combination topical preparations for vaginal infections (combined with sulfacetamide and sulfabenzamide) and historically for systemic bacterial infections before development of more effective agents. It inhibits dihydropteroate synthase in susceptible bacteria, blocking folate synthesis. Its combination use in triple sulfonamide vaginal preparations exploits synergistic antibacterial coverage against multiple pathogens.
Moleküler Ağırlık
255,3000 g/mol
LogP
0,10
TPSA
122,00 Ų
Lipinski RO5
Geçer
Etki Mekanizması
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
2D Yapı
Cite this structure
Embed this structure
SMILES
Nc1ccc(S(=O)(=O)Nc2nccs2)cc1
InChI
InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
Molecular Formula
C9H9N3O2S2
HBD / HBA
2 / 6
Döndürülebilir Bağlar
3
Ağır Atomlar
16
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
Sulfathiazole is a short-acting sulfonamide antibiotic used in combination topical preparations for vaginal infections (combined with sulfacetamide and sulfabenzamide) and historically for systemic bacterial infections before development of more effective agents. It inhibits dihydropteroate synthase in susceptible bacteria, blocking folate synthesis. Its combination use in triple sulfonamide vaginal preparations exploits synergistic antibacterial coverage against multiple pathogens.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Sulfathiazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL437. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5340. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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