Terodiline

CHEMBL363295 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

281.4 g/mol

LogP

5.0

Phase

4

Terodiline is an anticholinergic and calcium channel-blocking agent that was used for the treatment of urge urinary incontinence and overactive bladder through combined mechanisms of inhibiting detrusor muscle contraction. It was withdrawn from the market due to serious cardiac arrhythmias, including torsades de pointes, associated with QT prolongation. Its dual mechanism distinguished it from pure antimuscarinics but proved to have an unacceptable cardiac safety profile.

Moleküler Ağırlık

281,4000 g/mol

LogP

5,00

TPSA

12,00 Å²

Lipinski RO5

Geçer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

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SMILES

CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C

InChI

InChI=1S/C20H27N/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21H,15H2,1-4H3

Molecular Formula

C20H27N

HBD / HBA

1 / 1

Döndürülebilir Bağlar

6

Ağır Atomlar

21

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

Terodiline is an anticholinergic and calcium channel-blocking agent that was used for the treatment of urge urinary incontinence and overactive bladder through combined mechanisms of inhibiting detrusor muscle contraction. It was withdrawn from the market due to serious cardiac arrhythmias, including torsades de pointes, associated with QT prolongation. Its dual mechanism distinguished it from pure antimuscarinics but proved to have an unacceptable cardiac safety profile.

Yes, Terodiline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL363295. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 23480. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Terodiline PillFYI'da

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Hızlı Veriler

Formül: C20H27N

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.