Tolcapone

CHEMBL1324 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

273.2 g/mol

LogP

3.3

Phase

4

This medication is used as an add-on treatment to levodopa/carbidopa therapy in Parkinson's disease patients who are experiencing fluctuations in symptom control ("wearing off" episodes). It works by blocking an enzyme called COMT, which breaks down levodopa, allowing more of it to reach the brain. Due to the risk of serious liver damage, it requires regular liver function monitoring and is only used when other options have not worked.

Moleküler Ağırlık

273,2400 g/mol

LogP

3,30

TPSA

103,00 Å²

Lipinski RO5

Geçer

Terapötik Alanlar

Parkinson's Disease Schizophrenia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

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SMILES

Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1

InChI

InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3

Molecular Formula

C14H11NO5

HBD / HBA

2 / 5

Döndürülebilir Bağlar

2

Ağır Atomlar

20

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

This medication is used as an add-on treatment to levodopa/carbidopa therapy in Parkinson's disease patients who are experiencing fluctuations in symptom control ("wearing off" episodes). It works by blocking an enzyme called COMT, which breaks down levodopa, allowing more of it to reach the brain. Due to the risk of serious liver damage, it requires regular liver function monitoring and is only used when other options have not worked.

Yes, Tolcapone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1324. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 4659569. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Hızlı Veriler

Formül: C14H11NO5
Eş Anlamlılar: 1

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.