First-Pass Effect
The metabolism of an orally administered drug by the liver and/or gut wall before it reaches the systemic circulation. Drugs with high first-pass metabolism have low oral bioavailability despite good absorption.
Örnekler
- Nitroglycerin (sublingual to bypass)
- Morphine (~70% first-pass)
- Propranolol (~75% first-pass)
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The metabolism of an orally administered drug by the liver and/or gut wall before it reaches the systemic circulation. Drugs with high first-pass metabolism have low oral bioavailability despite good …