Half-Life (t1/2)
t1/2The time required for the plasma concentration of a drug to decrease by 50%. Determines dosing frequency and time to reach steady state (approximately 5 half-lives). Influenced by clearance and volume of distribution.
Örnekler
- Aspirin: ~20 min
- Metformin: ~6 hours
- Amiodarone: ~40-55 days
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The time required for the plasma concentration of a drug to decrease by 50%. Determines dosing frequency and time to reach steady state (approximately 5 half-lives). Influenced by clearance and …