Plasma Protein Binding Displacement
A pharmacokinetic interaction in which one drug displaces another from plasma protein binding sites (primarily albumin or alpha-1-acid glycoprotein), transiently increasing the free fraction of the displaced drug. Clinically significant displacement occurs mainly with highly protein-bound drugs that have a narrow therapeutic index and small volume of distribution.
Örnekler
- Valproic acid displacing phenytoin from albumin, raising free phenytoin levels
- Sulfonamides displacing bilirubin from albumin in neonates (kernicterus risk)
- Warfarin displacement by NSAIDs increasing free warfarin and bleeding risk
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A pharmacokinetic interaction in which one drug displaces another from plasma protein binding sites (primarily albumin or alpha-1-acid glycoprotein), transiently increasing the free fraction of the displaced drug. Clinically significant …