Moderate
Probable
Açıklama
Bupropion inhibits CYP2D6, modestly increasing quetiapine levels, while also lowering the seizure threshold — both risks are additive.
Mekanizma
Bupropion's CYP2D6 inhibition reduces quetiapine clearance modestly; both drugs also lower the seizure threshold via distinct mechanisms (dopaminergic + GABA effects vs. antipsychotic effects).
Klinik Önemi
The combination is used clinically for depression with psychosis but carries elevated seizure risk, particularly at higher bupropion doses.
Yönetim
Avoid high-dose bupropion; monitor for seizure activity; maintain quetiapine levels within the therapeutic range.