Moderate
Probable
Description
Bupropion inhibits CYP2D6, modestly increasing quetiapine levels, while also lowering the seizure threshold — both risks are additive.
Mécanisme
Bupropion's CYP2D6 inhibition reduces quetiapine clearance modestly; both drugs also lower the seizure threshold via distinct mechanisms (dopaminergic + GABA effects vs. antipsychotic effects).
Signification clinique
The combination is used clinically for depression with psychosis but carries elevated seizure risk, particularly at higher bupropion doses.
Prise en charge
Avoid high-dose bupropion; monitor for seizure activity; maintain quetiapine levels within the therapeutic range.