Afatinib vs Atezolizumab

## Afatinib vs Atezolizumab: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Atezolizumab**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Atezolizumab**: Fully human anti-PD-L1 IgG1 monoclonal antibody blocking PD-L1 interaction with PD-1 and B7.1.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Atezolizumab — 27 days.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Atezolizumab — N/A.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Atezolizumab — N/A.

**Type**: Afatinib — Small molecule; Atezolizumab — Antibody.