Hydrochlorothiazide vs Spironolactone

## Hydrochlorothiazide vs Spironolactone: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Spironolactone**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Spironolactone**: Mineralocorticoid receptor antagonist.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Spironolactone — 1.4 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Spironolactone — C24H32O4S.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Spironolactone — 416.5740 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Spironolactone — Small molecule.