Norfloxacin vs Trimethoprim

## Norfloxacin vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Norfloxacin** and **Trimethoprim**.

## Mechanism of Action

**Norfloxacin**: Second-generation fluoroquinolone inhibiting bacterial DNA gyrase and topoisomerase IV.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Norfloxacin — 3-4 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Norfloxacin — C16H18FN3O3; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Norfloxacin — 319.3310 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Norfloxacin — Small molecule; Trimethoprim — Small molecule.