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Amiloride

CHEMBL945 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
229.6 g/mol
LogP
-0.7
Phase
4

A potassium-sparing diuretic that blocks sodium channels in the kidney tubules, reducing sodium reabsorption and water retention without causing the potassium loss associated with most other diuretics. It is used to treat high blood pressure and fluid overload, often combined with potassium-wasting diuretics to maintain normal potassium levels.

Khối lượng phân tử

229,6300 g/mol

LogP

-0,70

TPSA

159,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Migraine Bipolar Disorder Gastroesophageal Reflux Disease Multiple Sclerosis Chronic Kidney Disease Obesity Type 2 Diabetes Hypertension Breast Cancer Heart Failure Cardiovascular Disease

Cơ chế tác dụng

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
N=C(N)NC(=O)c1nc(Cl)c(N)nc1N

                

                

                
                

                    
InChI

                    
InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H8ClN7O

                    

                    
                    

                        
HBD / HBA

                        
4 / 5

                    

                    
                    

                        
Liên kết có thể quay

                        
1

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A potassium-sparing diuretic that blocks sodium channels in the kidney tubules, reducing sodium reabsorption and water retention without causing the potassium loss associated with most other diuretics. It is used to treat high blood pressure and fluid overload, often combined with potassium-wasting diuretics to maintain normal potassium levels.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Amiloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL945.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 16231.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.