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Apremilast

CHEMBL514800 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
460.5 g/mol
LogP
1.8
Phase
4

A phosphodiesterase-4 inhibitor that reduces the production of inflammatory molecules inside immune cells, calming inflammation in conditions such as psoriasis and psoriatic arthritis. It is taken by mouth and is an option for patients who cannot use or have not responded to other treatments.

Khối lượng phân tử

460,5000 g/mol

LogP

1,80

TPSA

127,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Rheumatoid Arthritis Psoriasis Systemic Lupus Erythematosus Atopic Dermatitis Gout Cardiovascular Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC

                

                

                
                

                    
InChI

                    
InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H24N2O7S

                    

                    
                    

                        
HBD / HBA

                        
1 / 7

                    

                    
                    

                        
Liên kết có thể quay

                        
8

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A phosphodiesterase-4 inhibitor that reduces the production of inflammatory molecules inside immune cells, calming inflammation in conditions such as psoriasis and psoriatic arthritis. It is taken by mouth and is an option for patients who cannot use or have not responded to other treatments.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Apremilast is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL514800.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 11561674.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.