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Artemether

CHEMBL566534 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
298.4 g/mol
LogP
3.1
Phase
4

Semisynthetic derivatives of artemisinin act far faster than older antimalarials, and artemether is one of the principal members of that group. Its endoperoxide bridge is activated inside the parasite, generating reactive free radicals that damage parasite proteins and membranes and produce a rapid fall in parasitaemia. That speed comes with a short duration of action, which is why the compound is deployed within combination regimens: a longer-acting partner drug clears residual parasites and reduces the selection pressure that drives artemisinin resistance. The molecule is a small molecule of formula C16H26O5 with a molecular weight near 298.4 g/mol. It is an approved agent that has completed the final phase of clinical development.

A semisynthetic artemisinin derivative that rapidly kills malaria parasites by generating toxic free radicals inside the parasite after activation. It is most effective when combined with another antimalarial drug to prevent resistance.

Khối lượng phân tử

298,3700 g/mol

LogP

3,10

TPSA

46,20 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Malaria

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CO[C@H]1O[C@@H]2O[C@@]3(C)CC[C@H]4[C@H](C)CC[C@@H]([C@H]1C)[C@@]24OO3

                

                

                
                

                    
InChI

                    
InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H26O5

                    

                    
                    

                        
HBD / HBA

                        
- / 5

                    

                    
                    

                        
Liên kết có thể quay

                        
1

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A semisynthetic artemisinin derivative that rapidly kills malaria parasites by generating toxic free radicals inside the parasite after activation. It is most effective when combined with another antimalarial drug to prevent resistance.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Artemether is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL566534.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 68911.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.