Cefamandole Nafate Free Base
The free base form of cefamandole nafate is a parenteral second-generation cephalosporin prodrug converted to active cefamandole in the body. It is used for treating susceptible gram-positive and gram-negative bacterial infections. Caution is warranted regarding its interaction with alcohol and potential effects on vitamin K-dependent clotting factors.
Khối lượng phân tử
490,5000 g/mol
LogP
-0,30
TPSA
207,00 Ų
Lipinski RO5
Đạt
Cơ chế tác dụng
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](OC=O)c3ccccc3)[C@H]2SC1
InChI
InChI=1S/C19H18N6O6S2/c1-24-19(21-22-23-24)33-8-11-7-32-17-12(16(28)25(17)13(11)18(29)30)20-15(27)14(31-9-26)10-5-3-2-4-6-10/h2-6,9,12,14,17H,7-8H2,1H3,(H,20,27)(H,29,30)/t12-,14-,17-/m1/s1
Molecular Formula
C19H18N6O6S2
HBD / HBA
2 / 11
Liên kết có thể quay
9
Nguyên tử nặng
33
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
The free base form of cefamandole nafate is a parenteral second-generation cephalosporin prodrug converted to active cefamandole in the body. It is used for treating susceptible gram-positive and gram-negative bacterial infections. Caution is warranted regarding its interaction with alcohol and potential effects on vitamin K-dependent clotting factors.
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Yes, Cefamandole Nafate Free Base is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201218. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5284527. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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