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Chlophedianol

CHEMBL1201313 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
289.8 g/mol
LogP
3.6
Phase
4

Cough suppression by central action defines chlophedianol, which damps the cough reflex to relieve nonproductive cough rather than altering secretions in the airway. Mild antihistaminic and anticholinergic properties accompany that primary activity, and they account for part of the agent's side-effect profile. Formulations commonly combine it with other cough and cold ingredients rather than presenting it alone. The compound is a small molecule with the formula C17H20ClNO and a molecular weight of approximately 289.8 g/mol, and it is an approved agent whose clinical development reached the final phase. Its symptomatic role should be distinguished from that of expectorants and mucolytics, which target sputum rather than the reflex arc itself.

A centrally acting antitussive agent that suppresses the cough reflex to provide symptomatic relief from nonproductive cough. It is often used in combination with other cough and cold ingredients. It has mild antihistamine and anticholinergic properties in addition to its cough-suppressing activity.

Khối lượng phân tử

289,8000 g/mol

LogP

3,60

TPSA

23,50 Ų

Lipinski RO5

Đạt

Cơ chế tác dụng

A centrally acting non-opioid antitussive. Chlophedianol raises the threshold of the medullary cough centre, suppressing the cough reflex without acting at opioid receptors. It also carries mild local anaesthetic and anticholinergic activity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

A centrally acting non-opioid antitussive. Chlophedianol raises the threshold of the medullary cough centre, suppressing the cough reflex without acting at opioid receptors. It also carries mild local anaesthetic and …

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H20ClNO

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
5

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A centrally acting antitussive agent that suppresses the cough reflex to provide symptomatic relief from nonproductive cough. It is often used in combination with other cough and cold ingredients. It has mild antihistamine and anticholinergic properties in addition to its cough-suppressing activity.

                        

                    

                    

                    

                    
                    

                        
                        

                            
A centrally acting non-opioid antitussive. Chlophedianol raises the threshold of the medullary cough centre, suppressing the cough reflex without acting at opioid receptors. It also carries mild local anaesthetic and anticholinergic activity.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Chlophedianol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201313.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2795.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.