Chloroquine
An antimalarial and anti-inflammatory drug that interferes with heme detoxification in plasmodium parasites and modulates lysosomal pH and immune signaling in human cells. It is used to treat and prevent malaria caused by susceptible Plasmodium species and to treat autoimmune conditions including rheumatoid arthritis and lupus. Long-term use requires ophthalmologic monitoring due to the risk of irreversible retinal toxicity.
Khối lượng phân tử
319,9000 g/mol
LogP
4,60
TPSA
28,20 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI
InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)
Molecular Formula
C18H26ClN3
HBD / HBA
1 / 3
Liên kết có thể quay
8
Nguyên tử nặng
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
An antimalarial and anti-inflammatory drug that interferes with heme detoxification in plasmodium parasites and modulates lysosomal pH and immune signaling in human cells. It is used to treat and prevent malaria caused by susceptible Plasmodium species and to treat autoimmune conditions including rheumatoid arthritis and lupus. Long-term use requires ophthalmologic monitoring due to the risk of irreversible retinal toxicity.
Yes, Chloroquine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL76. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2719. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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