Chlortetracycline Hydrochloride
The hydrochloride salt form of chlortetracycline retains the broad-spectrum bacteriostatic activity of this early tetracycline antibiotic. In human medicine, it is now mainly found in topical ophthalmic preparations for conjunctivitis. Its systemic use has been replaced by newer tetracyclines with improved pharmacokinetics and tolerability.
Khối lượng phân tử
515,3000 g/mol
TPSA
182,00 Ų
Cơ chế tác dụng
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)ccc(Cl)c4[C@@](C)(O)[C@H]3C[C@@H]12.Cl
InChI
InChI=1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7-,8-,15-,21-,22-;/m0./s1
Molecular Formula
C22H24Cl2N2O8
HBD / HBA
7 / 9
Liên kết có thể quay
2
Nguyên tử nặng
34
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
The hydrochloride salt form of chlortetracycline retains the broad-spectrum bacteriostatic activity of this early tetracycline antibiotic. In human medicine, it is now mainly found in topical ophthalmic preparations for conjunctivitis. Its systemic use has been replaced by newer tetracyclines with improved pharmacokinetics and tolerability.
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Yes, Chlortetracycline Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2146063. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54682468. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="chlortetracycline-hydrochloride"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/chlortetracycline-hydrochloride/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/chlortetracycline-hydrochloride/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/chlortetracycline-hydrochloride/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="chlortetracycline-hydrochloride"></drugfyi-drug>