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Cimetidine Hydrochloride

CHEMBL1201051 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
288.8 g/mol
LogP
—
Phase
4

The hydrochloride salt formulation of cimetidine is used for parenteral administration in hospitalized patients requiring acid suppression. It shares the same H2 receptor blocking activity and drug interaction profile as the oral form. Gynecomastia and other anti-androgenic effects have been noted with higher doses due to its weak androgen receptor antagonism.

Khối lượng phân tử

288,8000 g/mol

TPSA

114,00 Ų

Cơ chế tác dụng

Irreversibly inhibits the hydrogen-potassium ATPase (proton pump) on the apical surface of gastric parietal cells. This blocks the final common pathway of gastric acid secretion, producing profound and sustained acid suppression.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Irreversibly inhibits the hydrogen-potassium ATPase (proton pump) on the apical surface of gastric parietal cells. This blocks the final common pathway of gastric acid secretion, producing profound and sustained acid …

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CN/C(=N\CCSCc1nc[nH]c1C)NC#N.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C10H16N6S.ClH/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11;/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H17ClN6S

                    

                    
                    

                        
HBD / HBA

                        
4 / 4

                    

                    
                    

                        
Liên kết có thể quay

                        
7

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
The hydrochloride salt formulation of cimetidine is used for parenteral administration in hospitalized patients requiring acid suppression. It shares the same H2 receptor blocking activity and drug interaction profile as the oral form. Gynecomastia and other anti-androgenic effects have been noted with higher doses due to its weak androgen receptor antagonism.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Irreversibly inhibits the hydrogen-potassium ATPase (proton pump) on the apical surface of gastric parietal cells. This blocks the final common pathway of gastric acid secretion, producing profound and sustained acid suppression.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Cimetidine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201051.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 50963.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.