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Cimetidine

CHEMBL30 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
252.3 g/mol
LogP
0.4
Phase
4

A first-generation H2 receptor antagonist that reduces gastric acid secretion by blocking histamine H2 receptors on parietal cells, used for peptic ulcer disease, gastroesophageal reflux disease, and pathological hypersecretory conditions. It is a potent inhibitor of several cytochrome P450 enzymes, leading to clinically significant drug interactions with many medications. It has largely been superseded by proton pump inhibitors for most acid-reducing indications.

Khối lượng phân tử

252,3400 g/mol

LogP

0,40

TPSA

114,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Non-Small Cell Lung Cancer Rheumatoid Arthritis Osteoporosis Chronic Obstructive Pulmonary Disease Generalized Anxiety Disorder Melanoma Gastroesophageal Reflux Disease Chronic Kidney Disease Breast Cancer Atopic Dermatitis Leukemia

Cơ chế tác dụng

Irreversibly inhibits the hydrogen-potassium ATPase (proton pump) on the apical surface of gastric parietal cells. This blocks the final common pathway of gastric acid secretion, producing profound and sustained acid suppression.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Irreversibly inhibits the hydrogen-potassium ATPase (proton pump) on the apical surface of gastric parietal cells. This blocks the final common pathway of gastric acid secretion, producing profound and sustained acid …

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CN/C(=N\CCSCc1nc[nH]c1C)NC#N

                

                

                
                

                    
InChI

                    
InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H16N6S

                    

                    
                    

                        
HBD / HBA

                        
3 / 4

                    

                    
                    

                        
Liên kết có thể quay

                        
7

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
17

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A first-generation H2 receptor antagonist that reduces gastric acid secretion by blocking histamine H2 receptors on parietal cells, used for peptic ulcer disease, gastroesophageal reflux disease, and pathological hypersecretory conditions. It is a potent inhibitor of several cytochrome P450 enzymes, leading to clinically significant drug interactions with many medications. It has largely been superseded by proton pump inhibitors for most acid-reducing indications.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Irreversibly inhibits the hydrogen-potassium ATPase (proton pump) on the apical surface of gastric parietal cells. This blocks the final common pathway of gastric acid secretion, producing profound and sustained acid suppression.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Cimetidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL30.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2756.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.