Dasatinib Anhydrous

CHEMBL1421 Phase 4 Đã phê duyệt Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

488.0 g/mol

LogP

3.6

Phase

4

The anhydrous crystal form of dasatinib, a BCR-ABL tyrosine kinase inhibitor used for CML and Ph+ ALL. The anhydrous form represents a specific polymorphic crystal structure used in pharmaceutical manufacturing.

Khối lượng phân tử

488,0000 g/mol

LogP

3,60

TPSA

135,00 Å²

Lipinski RO5

Đạt

Lĩnh vực điều trị

Pancreatic Cancer Lymphoma Breast Cancer Prostate Cancer Leukemia

Cơ chế tác dụng

Selectively inhibits specific receptor tyrosine kinases involved in tumor cell proliferation, angiogenesis, and survival signaling. By blocking ATP binding to the kinase domain, it prevents phosphorylation cascades that drive cancer cell growth.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Selectively inhibits specific receptor tyrosine kinases involved in tumor cell proliferation, angiogenesis, and survival signaling. By blocking ATP binding to the kinase domain, it prevents phosphorylation cascades that drive cancer …

Cấu trúc 2D

SVG PNG

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SMILES

Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1

InChI

InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

Molecular Formula

C22H26ClN7O2S

HBD / HBA

3 / 9

Liên kết có thể quay

7

Nguyên tử nặng

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Câu hỏi thường gặp

The anhydrous crystal form of dasatinib, a BCR-ABL tyrosine kinase inhibitor used for CML and Ph+ ALL. The anhydrous form represents a specific polymorphic crystal structure used in pharmaceutical manufacturing.

Selectively inhibits specific receptor tyrosine kinases involved in tumor cell proliferation, angiogenesis, and survival signaling. By blocking ATP binding to the kinase domain, it prevents phosphorylation cascades that drive cancer cell growth.

Yes, Dasatinib Anhydrous is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1421. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 3062316. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Cấu trúc

Dữ liệu nhanh

Công thức: C22H26ClN7O2S

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Tuyên bố miễn trách y tế

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.