Deferoxamine
An iron chelator derived from Streptomyces pilosus that binds free iron and aluminum, promoting their excretion in urine, used to treat acute iron poisoning and chronic iron overload from transfusion-dependent anemias. It must be given by injection or infusion.
Khối lượng phân tử
560,7000 g/mol
LogP
-2,10
TPSA
206,00 Ų
Lipinski RO5
Không đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI
InChI=1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)
Molecular Formula
C25H48N6O8
HBD / HBA
6 / 9
Liên kết có thể quay
23
Nguyên tử nặng
39
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
An iron chelator derived from Streptomyces pilosus that binds free iron and aluminum, promoting their excretion in urine, used to treat acute iron poisoning and chronic iron overload from transfusion-dependent anemias. It must be given by injection or infusion.
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Yes, Deferoxamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL556. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2973. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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