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Desloratadine

CHEMBL1172 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
310.8 g/mol
LogP
4.5
Phase
4

A non-sedating second-generation antihistamine that is the active metabolite of loratadine, used for allergic rhinitis, chronic hives, and allergic skin conditions. It selectively blocks peripheral H1 histamine receptors with minimal CNS penetration.

Khối lượng phân tử

310,8000 g/mol

LogP

4,50

TPSA

24,90 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Non-Small Cell Lung Cancer Asthma Multiple Sclerosis Breast Cancer Atopic Dermatitis

Cơ chế tác dụng

Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1

                

                

                
                

                    
InChI

                    
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H19ClN2

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
0

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A non-sedating second-generation antihistamine that is the active metabolite of loratadine, used for allergic rhinitis, chronic hives, and allergic skin conditions. It selectively blocks peripheral H1 histamine receptors with minimal CNS penetration.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Desloratadine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1172.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 124087.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.