Diphenoxylate Hydrochloride
The hydrochloride salt form of diphenoxylate, used in combination with atropine in oral liquid and tablet formulations for diarrhea treatment. It slows gut motility via opioid receptors in the intestinal wall. The small amount of atropine present discourages misuse.
Khối lượng phân tử
489,0000 g/mol
TPSA
53,30 Ų
Lĩnh vực điều trị
Cơ chế tác dụng
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CCOC(=O)C1(c2ccccc2)CCN(CCC(C#N)(c2ccccc2)c2ccccc2)CC1.Cl
InChI
InChI=1S/C30H32N2O2.ClH/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27;/h3-17H,2,18-23H2,1H3;1H
Molecular Formula
C30H33ClN2O2
HBD / HBA
1 / 4
Liên kết có thể quay
9
Nguyên tử nặng
35
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
The hydrochloride salt form of diphenoxylate, used in combination with atropine in oral liquid and tablet formulations for diarrhea treatment. It slows gut motility via opioid receptors in the intestinal wall. The small amount of atropine present discourages misuse.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Diphenoxylate Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200665. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6432394. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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