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Disopyramide

CHEMBL517 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
339.5 g/mol
LogP
3.2
Phase
4

A class IA antiarrhythmic drug used to treat and prevent ventricular arrhythmias and atrial fibrillation by blocking sodium channels in the heart, slowing conduction and reducing excitability. It also has significant anticholinergic effects, causing dry mouth, urinary retention, and constipation. It has negative inotropic effects and must be used cautiously in patients with heart failure.

Khối lượng phân tử

339,5000 g/mol

LogP

3,20

TPSA

59,20 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Cardiovascular Disease Heart Failure Atrial Fibrillation

Cơ chế tác dụng

Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H29N3O

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
Liên kết có thể quay

                        
8

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A class IA antiarrhythmic drug used to treat and prevent ventricular arrhythmias and atrial fibrillation by blocking sodium channels in the heart, slowing conduction and reducing excitability. It also has significant anticholinergic effects, causing dry mouth, urinary retention, and constipation. It has negative inotropic effects and must be used cautiously in patients with heart failure.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Disopyramide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL517.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3114.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.