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Gilteritinib

CHEMBL3301622 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
552.7 g/mol
LogP
3.5
Phase
4

A small molecule kinase inhibitor targeting FLT3 mutations in cancer cells, used to treat relapsed or refractory acute myeloid leukemia with these specific genetic alterations. By blocking mutated FLT3 signaling, it prevents leukemia cells from receiving growth signals they depend on. Genetic testing for FLT3 mutations is required before prescribing this medication.

Khối lượng phân tử

552,7000 g/mol

LogP

3,50

TPSA

121,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Non-Small Cell Lung Cancer Lymphoma Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1

                

                

                
                

                    
InChI

                    
InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)

                

                

                

                    
                    

                        
Molecular Formula

                        
C29H44N8O3

                    

                    
                    

                        
HBD / HBA

                        
3 / 10

                    

                    
                    

                        
Liên kết có thể quay

                        
9

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
40

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A small molecule kinase inhibitor targeting FLT3 mutations in cancer cells, used to treat relapsed or refractory acute myeloid leukemia with these specific genetic alterations. By blocking mutated FLT3 signaling, it prevents leukemia cells from receiving growth signals they depend on. Genetic testing for FLT3 mutations is required before prescribing this medication.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Gilteritinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3301622.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 49803313.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.