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Guanabenz

CHEMBL420 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
231.1 g/mol
LogP
1.7
Phase
4

A centrally acting alpha-2 adrenergic agonist used to treat hypertension by reducing sympathetic nervous system outflow from the brain, which lowers heart rate and relaxes blood vessels. It is taken orally and was used before newer antihypertensive agents became available. Abrupt discontinuation can cause rebound hypertension and should be avoided.

Khối lượng phân tử

231,0800 g/mol

LogP

1,70

TPSA

76,80 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Multiple Sclerosis Hypertension

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
N=C(N)N/N=C/c1c(Cl)cccc1Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H8Cl2N4

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
2

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A centrally acting alpha-2 adrenergic agonist used to treat hypertension by reducing sympathetic nervous system outflow from the brain, which lowers heart rate and relaxes blood vessels. It is taken orally and was used before newer antihypertensive agents became available. Abrupt discontinuation can cause rebound hypertension and should be avoided.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Guanabenz is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL420.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5702063.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.