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Ioflupane

CHEMBL1945778 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
431.3 g/mol
LogP
4.0
Phase
4

This radioactive imaging agent crosses the blood-brain barrier and binds to dopamine transporters in the brain, making it useful for distinguishing Parkinson's disease from other movement disorders on SPECT scans. A reduction in dopamine transporter activity shows up as reduced signal in the brain regions affected by Parkinson's disease.

Khối lượng phân tử

431,3000 g/mol

LogP

4,00

TPSA

29,50 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Pain Management Alzheimer's Disease Parkinson's Disease Chronic Pain

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COC(=O)[C@H]1[C@@H](c2ccc(I)cc2)C[C@@H]2CC[C@H]1N2CCCF

                

                

                
                

                    
InChI

                    
InChI=1S/C18H23FINO2/c1-23-18(22)17-15(12-3-5-13(20)6-4-12)11-14-7-8-16(17)21(14)10-2-9-19/h3-6,14-17H,2,7-11H2,1H3/t14-,15+,16+,17-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H23FINO2

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
23

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
This radioactive imaging agent crosses the blood-brain barrier and binds to dopamine transporters in the brain, making it useful for distinguishing Parkinson's disease from other movement disorders on SPECT scans. A reduction in dopamine transporter activity shows up as reduced signal in the brain regions affected by Parkinson's disease.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Ioflupane is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1945778.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 10048368.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.