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Ipratropium Bromide

CHEMBL2134724 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
412.4 g/mol
LogP
—
Phase
4

This bromide salt of ipratropium is the standard inhaled anticholinergic bronchodilator used for the maintenance treatment of COPD and acute management of asthma. It blocks muscarinic acetylcholine receptors in the lungs to relax airway smooth muscle and reduce secretions. It is also available as a nasal spray for rhinorrhea.

Khối lượng phân tử

412,4000 g/mol

TPSA

46,50 Ų

Lĩnh vực điều trị

Non-Small Cell Lung Cancer Asthma Chronic Obstructive Pulmonary Disease Parkinson's Disease Obesity Hypertension Heart Failure

Cơ chế tác dụng

Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC(C)[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2.O.[Br-]

                

                

                
                

                    
InChI

                    
InChI=1S/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1/t16-,17+,18+,19?,21?;;

                

                

                

                    
                    

                        
Molecular Formula

                        
C20H30BrNO3

                    

                    
                    

                        
HBD / HBA

                        
1 / 4

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
This bromide salt of ipratropium is the standard inhaled anticholinergic bronchodilator used for the maintenance treatment of COPD and acute management of asthma. It blocks muscarinic acetylcholine receptors in the lungs to relax airway smooth muscle and reduce secretions. It is also available as a nasal spray for rhinorrhea.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Ipratropium Bromide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2134724.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 657308.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.