Levamlodipine Maleate
A maleate salt form of levamlodipine, the active levorotatory enantiomer of amlodipine, used to treat high blood pressure and angina. By blocking calcium channels in blood vessel walls, it causes relaxation and widening of arteries, lowering blood pressure.
Khối lượng phân tử
524,9000 g/mol
TPSA
174,00 Ų
Lĩnh vực điều trị
Cơ chế tác dụng
Blocks L-type voltage-gated calcium channels in vascular smooth muscle and cardiac myocytes, reducing calcium influx during depolarization. This produces vasodilation, decreased myocardial contractility, and reduced heart rate.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks L-type voltage-gated calcium channels in vascular smooth muscle and cardiac myocytes, reducing calcium influx during depolarization. This produces vasodilation, decreased myocardial contractility, and reduced heart rate.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl.O=C(O)/C=C\C(=O)O
InChI
InChI=1S/C20H25ClN2O5.C4H4O4/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;5-3(6)1-2-4(7)8/h5-8,17,23H,4,9-11,22H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-;/m0./s1
Molecular Formula
C24H29ClN2O9
HBD / HBA
4 / 11
Liên kết có thể quay
12
Nguyên tử nặng
36
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
A maleate salt form of levamlodipine, the active levorotatory enantiomer of amlodipine, used to treat high blood pressure and angina. By blocking calcium channels in blood vessel walls, it causes relaxation and widening of arteries, lowering blood pressure.
Blocks L-type voltage-gated calcium channels in vascular smooth muscle and cardiac myocytes, reducing calcium influx during depolarization. This produces vasodilation, decreased myocardial contractility, and reduced heart rate.
Yes, Levamlodipine Maleate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4594288. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 69165622. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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