Nirmatrelvir
A protease inhibitor that blocks the SARS-CoV-2 main protease, preventing the virus from processing the proteins needed for replication. It is used in combination with ritonavir (as Paxlovid) to treat mild-to-moderate COVID-19 in high-risk adults.
Khối lượng phân tử
499,5000 g/mol
LogP
2,20
TPSA
131,00 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CC(C)(C)[C@H](NC(=O)C(F)(F)F)C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)N[C@H](C#N)C[C@@H]1CCNC1=O)C2(C)C
InChI
InChI=1S/C23H32F3N5O4/c1-21(2,3)16(30-20(35)23(24,25)26)19(34)31-10-13-14(22(13,4)5)15(31)18(33)29-12(9-27)8-11-6-7-28-17(11)32/h11-16H,6-8,10H2,1-5H3,(H,28,32)(H,29,33)(H,30,35)/t11-,12-,13-,14-,15-,16+/m0/s1
Molecular Formula
C23H32F3N5O4
HBD / HBA
3 / 8
Liên kết có thể quay
7
Nguyên tử nặng
35
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
A protease inhibitor that blocks the SARS-CoV-2 main protease, preventing the virus from processing the proteins needed for replication. It is used in combination with ritonavir (as Paxlovid) to treat mild-to-moderate COVID-19 in high-risk adults.
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Yes, Nirmatrelvir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4802135. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 155903259. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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